ceesdekker.net for Dummies
ceesdekker.net for Dummies
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Rotary movement of DNA rotors on nanopores. Prime row: raw online video on the Cy5 channel of each rotor. Center row: corresponding solitary-particle localization outcomes of the two finishes with the DNA rotors. The placement of the present body is marked as orange and blue dots, and also the trajectory of The ten frames ahead of the current body is shown as good traces.
Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.
Within the very same time, the group of Paul McEuen, who was then centered with the University of California, Berkeley, confirmed equivalent results on ropes of bundled nanotubes. Depending upon the wrapping angle, nanotubes can can be found in metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed working with scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of individual DNA molecules recaptured up to a thousand situations inside of a good point out nanopore
2010, created a brand new way (‘wedging transfer’) to manipulate nanostructures; to start with report of DNA translocation as a result of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into sound-state nanopores
Inside the a long time subsequent these discoveries, my study pursuits shifted to biophysics and nanobiology, And that i grew to become much less involved in the event of nanotube electronics. The main focus of many scientists in the sector also shifted to graphene (in which, funnily sufficient, the first graphene ribbons were being referred to as ‘nanotubes which can be Reduce open together their size’) right after the invention of The 2-dimensional materials in 2004.
Considering that 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling research of nucleosomes and DNA fix proteins to DNA translocation via nanopores. Recently his investigate has focused on studying mobile division with microorganisms on chip, whilst his top fascination is inside the direction of knowing synthetic cells.
Atomic force microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative fashion
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‘The fantastically subtle way in which features in mother nature operate never ceases to amaze me. If we solve the puzzle of how everyday living arrived into getting, I anticipate that my amazement at the complexity of generation could have improved and with it my awe for your greatness of your Creator.’
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from reports of cees dekker DNA loop extrusion and supercoiling to DNA translocation via nanopores. Additional not too long ago his research has centered on studying chromatin framework and cell division with micro organism on chip, whilst he is usually trying to finally Construct artificial cells from the bottom up.
Cees Dekker is Distinguished University Professor at TU Delft. Educated as being a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes inside the nineties. Given that 2000, he moved to solitary-molecule biophysics and nanobiology. His existing analysis focuses on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) building a living artificial mobile from lifeless molecules. Dekker is really an elected member with the KNAW and fellow on the APS along with the IOP.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever style in 2005. (nl)